Factions are NPC associations in Fallout 4. This is a list of the factions in the game. Your alliance to one of the 4 major factions will determine a significant portion of the story and Quests you have access to. At some point in the main story progression, you will have to choose alliance to 1 at the expense of the others. Spend some time getting to know each faction and their motivations before committing to their cause.

Completing the quests specified in the Factions Hostile Towards sections below will cause any of the remaining quests of the now hostile faction to fail/become unavailable. Consult the Quests order if you are trying to complete as many of the quests as possible during one playthrough. The game will prompt you prior to making 1 of these decisions.

Note that the Minutemen is the only faction who is not a target of hostility from any of the other factions, meaning that you can do any of the other factions' quest chain without alienating them, unless you do something specifically to them to make them hostile to your presence. However, if you wish to see their ending, you cannot start The Nuclear Option quest with another faction.

Factions